High Purity Lithium Heparin Anticoagulant Mechanism: Reversible Binding of Antithrombin III (ATIII)

• Customization: Available
• CAS No.: 9045-22-1
• Formula: N.a.
• Model NO.: Heparin Lithium Salt
• EINECS: 686-293-1
• Color: White
• Appearance: Powder
• Storage Conditions: Room Temp
• Form: Powder
• Water Solubility: Soluble
• Purity: Above 99%
• Molecular Weight: 0
• Primitive Trait: White Amorphous Powder
• Performance: Odorless, Soluble in Water, Easily Hy
• Potency: Greater Than 150iu/Mg
• Anhydrous Potency: Greater Than 160iu/Mg
• Average Molecular Weight: 15000
• Transport Package: Carton
• Specification: 10g/bottle, 20g/bottle, 50g/bottle
• Trademark: DeSheng
• Origin: Ezhou City, Hubei Province, China
• Production Capacity: 20 Kg Per Month

Product Description

Packaging Specification : 10g/bottle,20g/bottle,50g/bottle

Basic Information
 

Appearance	White crystal powder
Place of Origin	Ezhou City, Hubei Province
Soluble	Water: 125 mg/mL
Dissolution	Easily soluble in water
Titer	150IU/mg
Main use	Used as an external anticoagulant for blood

Heparin lithium is a chemical substance with a white to almost white powder appearance. There was no statistically significant difference in the detection results of TP, ASO, UA, ALT, Mg, Cl, TC, CRP between heparin lithium anticoagulant plasma and serum (P>0.05). There was a statistically significant difference in the detection results of HBD, LDH, and TChemicalbookBA between heparin lithium anticoagulant plasma and serum (P<0.05). Therefore, except for HBD, LDH, and TBA, the correlation between heparin lithium anticoagulant plasma and serum is good. Therefore, the feasibility of using heparin lithium anticoagulant plasma instead of serum in daily life testing is high, and it can be used as an important detection method.
   

Preparation of heparin lithium

1. Crude heparin enzymatic hydrolysis: Dissolve crude heparin sodium, adjust the pH value to 7.5-9.0, raise the temperature to 50-55 ºC, add heparin enzyme to hydrolyze pancreatic enzyme, keep it for 4-5 hours, adjust the pH value to 9.0-11, raise the temperature to 85 ºC~90 ºC, cool, filter to remove sediment, precipitate the filtrate with ethanol, and collect sediment (A);

2. Deproteinization: Dissolve the precipitate (A) obtained in step 1 with water, stir, adjust the pH to 9-11, add protein coagulant, stir, let stand, filter to remove the precipitate, collect the filtrate (D), adjust the pH of the filtrate (D) to 11-13, stir, let stand, filter to remove the precipitate, collect the filtrate (E), adjust the pH of the filtrate (E) to neutral, precipitate with ethanol, and collect the precipitate (ChemicalbookB);

3. Oxidative decolorization: Dissolve the precipitate (B) obtained in step 2 in water, oxidize it with hydrogen peroxide for 24-48 hours, adjust the pH to 10.5-11.5, filter to remove the precipitate, collect the filtrate (F), adjust the pH of the filtrate (F) to 6.5-7.5, precipitate with ethanol, and collect the precipitate (C);

4. Resin exchange: Dissolve the precipitate (C) obtained in step 3 with water, add LiCl, stir for dissolution, exchange ions through a resin column, collect the effluent from the column, and obtain a heparin lithium solution;

5. Precipitation, dehydration, and drying: Filter the heparin lithium solution obtained in step 4, precipitate with ethanol, collect the precipitate (G), dehydrate the precipitate (G), and then vacuum dry and crush to obtain a high-quality heparin lithium product.
 

Physical and chemical properties

Although sodium and lithium are both alkali metals, lithium is composed of two stable isotopes Li6 and Li7. The conductivity of Li/10E6/cm: 0.108, the number of nuclear charges 3, and the extranuclear electron layer 1. Lithium has small density and viscosity, while Li7 has the advantage of small neutron capture area, which is only 6.2% of sodium. Lithium has fewer electrons and is relatively stable, so it is slower to combine with PLT than heparin sodium. The conductivity of sodium/10E6/cm: 0.21, nuclear charge number 11, and outer electron layer 6. From the comparison of these three values of the two elements, lithium has more stable chemical properties than sodium. Sodium has more nuclear charges and aggregates more quickly with negatively charged PLTs than heparin lithium.
 

Full series of blood collection additives produced by Desheng
 

Order number	Product name	CAS Number
1	Serum Separating Gel	/
2	Sodium Heparin	9041-08-1
3	Lithium Heparin	9045-22-1
4	EDTA K2	25102-12-9
5	EDTA K3	65501-24-8
6	EDTA Na2	6381-92-6
7	Blood Clot Activation	/
8	Blood Clot powder	/
9	Water Soluble Silicone Release Agent	/
10	High effective Silicone release agent	/
11	Potassium oxalate monohydrate	6487-48-5
12	Trisodium citrate dihydrate	6132-04-3

Company Introduction

Hubei New Desheng Material Technology Co., Ltd. specializes in the production of blood collection tube additives, chemiluminescent reagents, biological buffers, chromogenic substrates, enzyme preparations, antigen antibodies and other biochemical reagents. Founded in 2005, Desheng has a professional R&D team and advanced production equipment!